| Product Name | Laforin Antibody: ATTO 700 |
|---|---|
| Description | Laforin, also known as Lafora PTPase, is a dual specificity protein phosphatase. Laforin is involved in the control of glycogen metabolism, specifically in preventing the formation of poorly branched glycogen molecules (polyglucosans). Laforin forms a complex with NHLRC1/malin and HSP70 that suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Laforin is expressed in heart, skeletal muscle, kidney, pancreas and brain. Defective Laforin is linked to progressive myoclonic epilepsy type 2 (EPM2). Mouse Anti-Human Laforin Monoclonal IgG1 |
| Synonyms | EPM2 Antibody, Epilepsy progressive myoclonus type 2 Lafora disease (laforin) Antibody, Epilepsy progressive myoclonus type 2A Lafora disease (laforin) Antibody, EPM2 Antibody, Epm2a Antibody, Lafora PTPase Antibody, LAFPTPase Antibody, LD Antibody, LDE A |
| Host | Mouse |
| Clone | S84-37 |
| Immunogen |
Fusion protein amino acids 1-331 (full-length) of human Laforin. Rat: 90% identity (296/327 amino acids identical). Mouse: 89% identity (295/327 amino acids identical) |
| Isotype | IgG1 |
| Specificity | Detects ~40kDa. |
| Reactivity | Human |
| Applications | ICC, IF, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Gene Id | NP_001018051.1. 7957 |
| Uniprot | O95278 |
| Supplier | Stressmarq Biosciences |
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