| Product Name | Methylglyoxal Antibody: RPE |
|---|---|
| Description | Lipid peroxidation occurs when oxidizing agents attack carbon-carbon double bonds found in unsaturated lipids. In addition to membrane degradation, oxidation end-products have been found to damage cell viability through their mutagenic and toxic properties. These downstream functional consequences facilitate the development of disease and premature aging. Methylglyoxal is an alpha-oxoaldehyde generated from lipid peroxidation that reacts with proteins to form adducts(1). It reacts with free amino acids and protein residues to generate advanced glycation endproducts (AGEs) and crosslinks DNA polymerase and substrate DNA to severely inhibit DNA replication (2). Mouse Anti-Methylglyoxal (MG) Monoclonal IgG2a |
| Synonyms | Methylglyoxal Antibody, 2-Oxopropanal Antibody, 2 oxo propanal Antibody, MG Antibody, Pyruvaldehyde Antibody, Methylglyoxal (MG) Antibody, MG-modified protein Antibody |
| Host | Mouse |
| Clone | 9E7 |
| Immunogen | Synthetic Methylglyoxal modified Keyhole Limpet Hemocyanin (KLH). |
| Isotype | IgG2a |
| Specificity | Specific for Methylglyoxal modified proteins. Does not detect free Methylglyoxal. Does not cross-react with Acrolein, Hexanoyl Lysine, Malondialdeyhde, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, or Crotonaldehyde modified proteins. |
| Applications | ELISA, FACS, FCM, ICC, IF, IHC, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide |
| Supplier | Stressmarq Biosciences |
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