Mitofusin 2 Antibody: ATTO 488

Category: Antibodies
Catalog
SMC-457D-A488
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Product Name Mitofusin 2 Antibody: ATTO 488
Description Mitofusin-2 (Mfn2) is a membrane protein of the mitochondria and is important in mitochondrial fusion in mammalian cells. Mfn2 activity has also been implicated in mitochondrial metabolism and the loss of Mfn2 may be the reason for certain metabolic modifications that are seen in individuals with obesity. Mfn2 has been associated with maintaining the membrane potential of the mitochondria. Mfn2 has been shown to hinder mitochondrial antiviral signaling by inhibiting production of type 1 interferons. Mfn2 is a p53-inducible target and involved in cell proliferation, apoptosis promotion and tumor suppression. Mouse Anti-Human Mitofusin 2 Monoclonal IgG2a
Synonyms CMT2A Antibody, CMT2A2 Antibody, CPRP 1 Antibody, CPRP1 Antibody, Fzo Antibody, HSG Antibody, hyperplasia suppressor gene Antibody, Hypertension related protein 1 Antibody, KIAA0214 Antibody, MARF Antibody, MFN 2 Antibody, Mfn2 Antibody, Mitochondrial ass
Host Mouse
Clone S153-5
Immunogen Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
Isotype IgG2a
Specificity Detects ~90kDa. No cross-reactivity against Mitofusin-1.
Reactivity Human, Mouse, Rat
Applications ICC, IF, IHC, WB
Form Purified, in PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Gene Id NP_573464.2. 170731
Uniprot Q80U63
Supplier Stressmarq Biosciences

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