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|Product Name||MLF1IP, 147-418a, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSTRRKVKS AEKISTQRHE VIRTTASSEL SEKPAESVTS KKTGPLSAQP SVEKENLAIE SQSKTQKKGK
ISHDKRKKSR SKAIGSDTSD IVHIWCPEGM KTSDIKELNI VLPEFEKTHL EHQQRIESKV CKAAIATFYV NVKEQFIKML KESQMLTNLK
RKNAKMISDI EKKRQRMIEV QDELLRLEPQ LKQLQTKYDE LKERKSSLRN AAYFLSNLKQ LYQDYSDVQA QEPNVKETYD SSSLPALLFK
ARTLLGAESH LRNINHQLEK LLDQG
|Background||MLF1IP, as known as centromere, is a specialized chromatin domain, present throughout the cell cycle that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. It plays an important role in the correct PLK1 localization to the mitotic kinetochores. It is a scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. It also involved in transcriptional repression. Recombinant human MLF1IP protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl (pH8.0) containing 20% glycerol,
0.15M NaCl, 1mM DTT
|Intended Use||For Research Use Only|
|Molecular Weight||47.2kDa (429aa) confirmed by MALDI-TOF|
|NCBI Accession #||NP_078905|
|Purity||> 80% by SDS-PAGE|
|References||Foltz DR. et al. (2006) Nat Cell Biol. 8:458-469.|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||CENP50, CENPU, CENPU50, KLIP1, PBIP1|
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