Mouse Lipolysis-stimulated lipoprotein receptor (LSR) ELISA Kit

Category: Assay Kits
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AE34899MO
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Product Name Mouse Lipolysis-stimulated lipoprotein receptor (LSR) ELISA Kit
Description LSR is a multimeric protein complex in the liver that undergoes conformational changes upon binding of free fatty acids, thereby revealing a binding site (s) that recognizes both apoB and apoE. Complete inactivation of the LSR gene is embryonic lethal in mice.LSR cooperates with the LDL receptor in the final hepatic processing of apoB-containing lipoproteins and represents a novel therapeutic target for the treatment of hyperlipidemia associated with obesity and atherosclerosis. The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids. Antibodies inhibiting LSR functions showed that the receptor is a heterotrimer or tetramer consisting of 68-kDa (alpha) and 55-kDa (beta) subunits associated through disulfide bridges. This assay has high sensitivity and excellent specificity for detection of Mouse LSR. No significant cross-reactivity or interference between Mouse LSR and analogues was observed.
Synonyms ILDR3, LISCH7, MGC10659, MGC48312, MGC48503, LISCH protein|immunoglobulin-like domain containing receptor 3|lipolysis-stimulated receptor|lipolysis-stimulated remnant|liver-specific bHLH-Zip transcr
Method Sandwich ELISA
Detection Range 0.156-10 ng/mL
Sensitivity 0.059 ng/mL
Reactivity Mouse
Sample Types Serum, Plasma, Other biological fluids.
Supplier Abebio

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