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|Product Name||MX2, 626-715aa, Human|
|Amino Acid Sequence||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSIGIH LNAYFLETSK RLANQIPFII QYFMLRENGD SLQKAMMQIL QEKNRYSWLL QEQSETATKR RILKERIYRL TQARHALCQF SSKEIH|
|Background||MX2 has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. Recombinant human MX2 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||34.3 kDa (303aa)|
|NCBI Accession #||NP_002454.1|
|Purity||> 90% by SDS-PAGE|
|References||Melén K, Keskinen P, et al. (1996). J Biol Chem. 271(38):23478-86.
al-Masri AN, Werfel T, et al. (1997). Mol Pathol. 50(1):9-14.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Myxovirus resistance protein 2, MXB|
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