Nitrotyrosine Antibody: PerCP

Category: Antibodies
Catalog
SMC-154D-PCP
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Product Name Nitrotyrosine Antibody: PerCP
Description Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4). Mouse Anti- Nitrotyrosine Monoclonal IgG2a
Synonyms Nitro tyrosine Antibody, 3-Nitrotyrosine Antibody
Host Mouse
Clone 39B6
Immunogen Hybridoma line 39B6
Isotype IgG2a
Specificity Recognizes 3-nitrotyrosine moieties. No detectable cross-reactivity with non-nitrated tyrosine. Not species specific.
Applications AM, ELISA, FCM, ICC, IF, IHC, IP, WB
Form Purified, in PBS, 50% glycerol, 0.09% sodium azide
Supplier Stressmarq Biosciences

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