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|Product Name||PA1, 1-254aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSLARGHGDT AASTAAPLSE EGEVTSGLQA LAVEDTGGPS ASAGKAEDEG EGGREETERE GSGGEEAQGE VPSAGGEEPA EEDSEDWCVP CSDEEVELPA DGQPWMPPPS EIQRLYELLA AHGTLELQAE ILPRRPPTPE AQSEEERSDE EPEAKEEEEE KPHMPTEFDF DDEPVTPKDS LIDRRRTPGS SARSQKREAR LDKVLSDMKR HKKLEEQILR TGRDLFSLDS EDPSPASPPL RSSGSSLFPR QRKY|
|Background||PA1 is a component of a Set1-like multiprotein histone methyltransferase complex. It interacts with PAXIP1/PTIP; the interaction is direct and is required for the association with the rest of the PTIP complex. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. Recombinant human PA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 100mM NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||35.0 kDa (330aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_078792|
|Purity||> 85 % by SDS-PAGE|
|References||Liang J., et al. (2009) EMBO Rep. 10(1):51-7.
Cho YW., et al. (2007) J Biol Chem. 282(28):20395-406.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||PAXIP1-associated protein 1., FLJ22459, GAS, MGC4606, C16orf53.|
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