PFDN6, 1-129aa, Human

Proteins, Recombinant
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Product Name PFDN6, 1-129aa, Human
Applications SDS-PAGE
Background PFDN6, also known as HKE2 or PFD6, is a subunit of the heteromeric prefoldin complex that chaperones nascent actin and alpha- and beta-tubulin chains pending their transfer to the cytosolic chaperonin containing TCP1 (CCT) complex. It binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it and binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Recombinant human PFDN6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 0.5 mg/ml (determined by Bradford assay)
Form Liquid, in 20 mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 30.9 kDa (273aa) confirmed by MALDI-TOF
NCBI Accession # NP¬_055075
Purity > 95% by SDS-PAGE
References Sowa ME., et al. (2009) Cell. 138(2):389-403.
Simons CT., et al. (2004) J Biol Chem. 279(6):4196-203.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Prefoldin subunit 6, H2-KE2, HKE2, KE-2, MGC70744, PFD6
Tag His-tag

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