PNRC2, 1-139aa, Human

Proteins, Recombinant
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Product Name PNRC2, 1-139aa, Human
Applications SDS-PAGE
Background PNRC2 is involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. This protein may act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. It is required for UPF1/RENT1 localization to the P-body and also acts as a nuclear receptor coactivator. PNRC2 may play a role in controlling the energy balance between energy storage and energy expenditure. Recombinant human PNCR2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Concentration 0.25 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 41.7 kDa (385aa), confirmed by MALDI-TOF
NCBI Accession # NP_060231
Purity > 90% by SDS-PAGE
References Hentschke,M., et al. (2003) Biochem. Biophys. Res. Commun. 312 (4), 975-982
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Proline-rich nuclear receptor coactivator 2, HSPC208
Tag His-tag

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