Anti-GABA B receptor GB1b subunit Polyclonall Antibody

Category: Antibodies
Catalog
11-550-C100
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Product Name Anti-GABA B receptor GB1b subunit Polyclonall Antibody
Description GABA B receptor is a G-protein-coupled inhibitory receptor of gamma-aminobutyric acid (GABA), and has important functions in brain by inhibition of adenylyl cyclase and modulation of G-protein-gated Ca2+ and K+ channels. GABA B receptor is comprised of two subunits, GB1 and GB2 with N-terminal extracellular and C-terminal intracellular domains. The GB1 subunit plays a critical role in ligand binding, whereas the GB2 subunit contains the determinants required for G-protein signaling. Multiple allosteric interactions between the two subunits are required for correct functioning of the receptor. There are two N-terminal splice variants of GB1 subunit, termed GB1a and GB1b; their expression in the central nervous system changes during the ontogenesis and differs between various regions of the brain.
Clone Polyclonal
Immunogen Synthetic peptide (coupled with THG) derived from amino acid sequence 30-47 of mouse GABA B receptor 1b. Only 1 amino acid is different from immunogen derived from human GB1b.
Specificity The polyclonal antibody recognizes N-terminus of mouse gamma-aminobutyric acid (GABA) B receptor 1b. GB1b apparent MW ~100 kDa.
Reactivity Mouse, Rat
Applications ICC, WB
Form Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Store at 2-8°C. Do not freeze.
Supplier Exbio

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