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|Product Name||Anti-H5N1/HA1 (clone AT2B7)|
|Description||H5N1 is a subtype of the species Influenza A virus of the Influenzavirus A genus of the Orthomyxoviridae family. consists of single-stranded eight-segment negative-sense genomic RNAs, helical viral ribonucleoprotein (RNP) complexes (RNA segments NP, PB2, PB1 and PA), three viral envelope proteins (hemagglutinin [HA], neuraminidase [NA], and M2 ion channel), and a maxtir (M1) protein. Influenza A viruses are further classified into 16 HA (H1-H16) and 9 NA (N1-N9) serotypes based on the antigenic characteristics of HA and NA envelope glycoproteins. It is responsible for binding the virus to the cell that is being infected. HA protein has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding of these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.|
|Applications||Dot blot, ELISA, WB|
|Clone||AT2B7. Anti-human H5N1/HA1 mAb, clone 2B7, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human H5N1/HA1 protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide|
|Immunogen||Recombinant human H5N1/HA1 (17-338aa) purified from Baculovirus|
|References||Song D., et al. (2008) Emerg. Infect. Dis. 14:741-746Li S., et al. (2010) Infect. Genet. Evol. 10:1286-1288Horimoto T, Kawaoka Y (2005) Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol 3: 591600.|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Hemagglutinin, Influenza A virus (A/Vietnam/HN31242/2007H5N1) haemagglutinin|
|Working Dilutions||Optimal dilution should be performed by user.|
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