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|Product Name||Anti-KLF7 (clone AT3G3)|
|Description||KLK7 is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation, survival and the development of nervous systems.and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. KLF7 is binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.|
|Applications||Dot blot, ELISA, WB|
|Clone||AT3G3. Anti-human KLF7 mAb, clone AT3G3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KLF7 protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.|
|Immunogen||Recombinant human KLF7 (1-302aa) purified from E. coli|
|References||Matsumoto, N., et al. (1998) J Biol Chem 273(43): 28229-37Kanazawa, A., et al. (2005) Diabetologia 48(7): 1315-22|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Kruppel-like factor 7, UKLF|
|Working Dilutions||Optimal dilution should be performed by user.|
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