Anti-KLF7 (clone AT3G3)

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01-A0256
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Product Name Anti-KLF7 (clone AT3G3)
Description KLK7 is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation, survival and the development of nervous systems.and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. KLF7 is binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.
Applications Dot blot, ELISA, WB
Clone AT3G3. Anti-human KLF7 mAb, clone AT3G3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KLF7 protein.
Concentration 0.1 mg/ml
Form Purified, in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.
Immunogen Recombinant human KLF7 (1-302aa) purified from E. coli
Interest Fields Epigenomics
Isotype IgG1, K
NCBI Number NP_003700
Reactivity Human
References Matsumoto, N., et al. (1998) J Biol Chem 273(43): 28229-37Kanazawa, A., et al. (2005) Diabetologia 48(7): 1315-22
Species Mouse
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Synonyms Kruppel-like factor 7, UKLF
Working Dilutions Optimal dilution should be performed by user.
Host Mouse

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