Anti-ABRA1 Monoclonal Antibody

Category: Antibodies
Catalog
11-619-C100
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Product Name Anti-ABRA1 Monoclonal Antibody
Description ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
Clone ABRA1-01
Immunogen Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
Isotype IgG
Specificity The mouse monoclonal antibody ABRA1-01 recognizes N-terminal part of ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.
Reactivity Human
Applications FC, IP, WB
Form Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Store at 2-8°C. Do not freeze.
Supplier Exbio

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