Anti-Adeno-Associated Virus (AAV), Rep Protein

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03-65171
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Antibodies, Monoclonal Antibodies, Anti-AAV Products
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Product Name Anti-Adeno-Associated Virus (AAV), Rep Protein
Description Mouse Monoclonal Antibody to Adeno-Associated Virus (AAV), Rep Protein. Recognizes AAV replicase proteins Rep 78, Rep 68, Rep 52 and Rep 40 in human AAV-2-infected cells. Cross-reactivity with AAV serotypes 1, 3, 4, 5, and 6.
Background Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Clone 259.5
Immunogen Rec.AAV-2 Rep 78 protein, N-terminally truncated by 171 aa
Specificity Mab 259.5 reacts with Rep proteins (Rep78, Rep68, Rep52 and Rep40) of human AAV-2-infected cells
Form Hybridoma culture supernatant
Reactivity 3, 4, 5 and 6, AAV-2, Found in human and also with serotypes 1
Applications WB
Working Dilutions 1:10 for immunoblotting; dilute further when using the ECL method
Storage 2-8C
Intended Use For Research Use Only
References Wobus,CE. et al. (2000) J. Virol 74 (19): 9281-9292Wistuba, A. et al. (1995) J. Virol. 69: 5311-5319
Isotype IgG1

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