Anti-Adeno-Associated Virus (AAV), Rep Protein, clone 226.7

Antibodies, Monoclonal Antibodies, Anti-AAV Products
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Product Name Anti-Adeno-Associated Virus (AAV), Rep Protein, clone 226.7
Description Mouse Monoclonal Antibody to Adeno-Associated Virus (AAV), Rep Protein. Recognizes AAV replicase proteins Rep 78, Rep 68, Rep 52 and Rep 40 in AAV-infected cells. In Immunoblotting prominant reaction with Rep 78 and Rep 68, only faint reaction with Rep 52 and Rep 40.
Background Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Clone 226.7
Immunogen Rec.AAV-2 Rep 78 protein, N-terminally truncated by 171 aa
Specificity Mab 226.7 reacts with Rep proteins (Rep78, Rep68, Rep52 and Rep40) of human AAV-2-infected cells. The antibody shows low affinity which is most useful in affinity chromatography experiments where mild conditions can be used for dissociation of the antigen. In immunoblotting it reacts mainly with Rep52 and Rep40, faint reaction with Rep78 and Rep68 (long incubation time and short wash- ing steps are recommended). Alternatively for immunoblotting cat. nos. 03-61069 /03-65169 and 03-61071 /03-65171 and for immunofluorescence micros- copy cat. nos. 03-61073/03-65173 are suggested.
Form Hybridoma culture supernatant
Reactivity AAV-2, Found in human and monkey
Applications IF, IP, WB
Working Dilutions 1:2 for immunoblotting; dilute further when using ECL method
Isotype IgG1
Storage 2-8C
Intended Use For Research Use Only

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