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|Product Name||Anti-Adeno-associated virus (AAV), VP1/VP2/VP 3|
|Description||Mouse Monoclonal Antibody to Adeno-associated virus (AAV), VP1,VP2, VP3. Useful for immunolocalization studies of capsid formation in combination with monoclonal antibody A20 (03-61055/65155) and rabbit polyclonal antibody to AAV capsid proteins (03-61084). Reacts with free VP1, VP2 and VP3 and at a very reduced level with assembled capsids. Recognizes all AAV-serogroups 1-6 (4 reacts weaker).|
|Background||Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models|
|Immunogen||Adeno-associated virus capsid proteins and virus particles|
|Specificity||B1 reacts with free VP1, VP2 & VP3 of adeno-associated virus and trace amounts of assembled capsids. VP1 and VP2 distributed in the nucleus and the cytoplasm. Epitope mapping experiments (Wobus et al.) identified aa726 to aa733 (C-terminus, common to all 3VP proteins) as the specific binding region. The antibody is also useful for characterization of different stages of infection.|
|Form||Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide|
|Reactivity||(AAV-4 only weak cross reaction), AAV-2, In human & monkey, Recognizes AAV serogroups 1-6|
|Applications||IF, IHC, IP|
|Working Dilutions||1:10 for immunohistochemistry|
|Storage||2-8C for immediate use, or at -20C (aliquot)|
|Intended Use||For Research Use Only|
|References||Wistuba A, et al. (1995), J. Virol, 69: 5311-5319Wistuba A, et al. (1997), J. Virol, 71: 1341-1352Wobus,CE. et al. (2000) J. Virol 74 (19): 9281-9292Sato Y et al. (1999) Jpn J Infect Dis 52Zhang H-G et al. (2002) J virology 76: 12023-12031Yan Z et al. (2002) J Virology 76: 2043-2055|
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