Anti-Adeno-associated virus (AAV), VP1, VP2, VP3

Antibodies, Monoclonal Antibodies, Anti-AAV Products
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Product Name Anti-Adeno-associated virus (AAV), VP1, VP2, VP3
Description Mouse Monoclonal Antibody to Adeno-associated virus (AAV), VP 1 & VP2. A69 reacts with VP 1 and VP 2 of adeno-associated virus which are highly enriched in the nucleus. Recognizes AAV-2 viral capsid proteins VP1 and VP2, which are highly enriched in the nucleus. Weak cross-reaction with serogroups 1, 3, and 6.
Background Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Synonyms AAV2
Clone A69
Immunogen Adeno-associated virus capsid proteins and virus particles
Specificity Epitope mapping experiments (Wobus et al.) identified aa 169 to aa 184 of VP2 and (with reduced intensity) aa 123 to aa136 of VP1 capsid proteins as the specific binding region.
Form Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide
Reactivity 3 and 6, AAV-2, Human, Monkey. Weak cross reaction with serotypes 1
Applications IF, IHC, IP, WB
Working Dilutions 1:10 for immunohistochemistry
Storage 2-8C for immediate use, or at -20C (aliquot)
Intended Use For Research Use Only
References Wistuba, A. et al. (1995) J. Virol. 69: 5311-5319Wistuba, A. et al. (1997) J. Virol. 71: 1341-1352Wobus,CE. et al. (2000) J. Virol 74 (19): 9281-9292
Isotype IgG1

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