Anti-Adeno-associated virus type 5 (AAV-5), intact particles

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03-610148
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Antibodies, Monoclonal Antibodies, Anti-AAV Products
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Product Name Anti-Adeno-associated virus type 5 (AAV-5), intact particles
Description Mouse Monoclonal Antibody to Adeno-Associated Virus, serotype 5 (AAV-5), intact particles. Specifically detects intact virus particles, both empty and full capsids. ADK5a recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. The antibody is not suitable for Immunoblotting.
Background Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Synonyms AAV5
Clone ADK5a
Immunogen Adeno-associated virus type 5 (AAV-5) capsid proteins and virus particles
Specificity For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK5a specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids, not present in denatured capsid proteins and native but unassembled capsid proteins.
Form Affinity purified, 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4
Reactivity AAV-5 found in human & monkey
Applications ELISA, IF, IHC, IP, Neutralizing
Working Dilutions 1:20 for Immunofluorescence microscopy 1:5 for Immunoprecipitation
Storage 2-8C for immediate use, or at -20C (aliquot)
Intended Use For Research Use Only
References Kuck, D et al. (2007) Virol Methods 140: 17-24
Isotype IgG2a, Kappa

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