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|Description||Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha-synuclein, beta-Synuclein, and gamma-Synuclein. All Synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable apolipoproteins. Although they are homologous, each Synuclein is encoded by a different gene on chromosomes 4q21.3-q22. beta-Synuclein, also known as PNP 14, is expressed in the brain, specifically in synapses around neurons, but not in glial cells. The protein, which has also been designated as a phosphoneuroprotein, has been found to be phosphorylated in vitro and in vivo|
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