Anti-CD59 Monoclonal Antibody

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08-9409-2
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Antibodies, Monoclonal Antibodies
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Product Name Anti-CD59 Monoclonal Antibody
Description Mouse monoclonal antibody to human CD59 Affinity purified. CD59 (also known as HRF20, MIRL, P18, H19, MAC-inhibitor) is a cell surface glycoprotein of apparent molecular weight 18-20 kDa which contains N- glycans. It is attached to the cell surface by a glycosylphosphatidylinositol tail. The full amino acid sequence derived from cDNA is known. CD59 has been mapped to chromosome 11p14-. It is a complement regulatory protein. It inhibits the terminal stage of the formation of membrane attack complexes by homologous complement activation. CD59 is broadly distributed among haemopoietic and non - haemopoietic cells such as B cells, T cells, monocytes, epithelium, platelets, polymorphonuclear neutrophils and endothelium. Daudi and U937 cells are unreactive. There are approximately 20000-40000 CD59 molecules per erythrocyte. There is reduced expression of CD59 on cells of individuals with paroxysmal nocturnal haemoglobinuria (PNH).
Synonyms CD59, HRF20, MIRL, P18, H19, MAC-inhibitor
Clone BRIC 229
Immunogen BRIC 229 was made in response to human erythrocytes. The antigen on erythrocytes is sensitive to treatment with Pronase or 6% aminoethylisothiouronium bromide.
Form Affinity purified, in 0.1 M glycine buffer, 1 M Tris buffer, pH 7.4, sterile filtered
Reactivity Human
Applications Neutralizing, WB
Isotype Mouse IgG2b kappa light chain
Storage 2-8C for immediate use, or at -20C (aliquot)
Intended Use For Research Use Only
References 1. Ojcius et al (1990) Immunology Today 11, 47-49 (Review).

2. Hadam M.R. (1989) in Leucocyte Typing IV; White Cell Differentiation Antigens Ed. W. Knapp et al Oxford University Press pp 720-722.

3. Fletcher A et al. (1992) Immunology, 75: 507-512.

4. van den Berg CW et al.( 1994) J. Immunol., 4095-4101.

5. Zaltzman et al., (1995) Biochem. J., 307: 651-656.

6. Klickstein et al., (1993) Proceedings of the fifth workshop and conference on white cell differentiation antigens, Boston , vol. 2 p1476-1477.

All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.

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