Anti-EGFR (clone AT2H8)

Catalog
01-A0212
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Antibodies, Monoclonal Antibodies
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Product Name Anti-EGFR (clone AT2H8)
Description Epidermal growth factor receptor (EGFR) is a 170 kDa membrane protein first identified as a binding partner of EGF. Also, EGFR phosphorylated itself (autophosphorylation) in response to EGF treatment. The overexpression of EGFR in various epithelial tumors was widely reported and it has been substantiated that deregulation of EGFR itself and its signaling pathways an important role in human cancers.
Synonyms ERBB, ERBB1, Epidermal growth factor receptor, HER1, PIG61, epidermal growth factor receptor, Urogastrone, Proto-oncogene c-ErbB-1, Oncogene ERBB, Cell proliferation inducing protein 61, Cell growth inhibiting protein 40, Avian erythroblastic leukemia viral (verbb) oncogene homolog
Host Mouse
Clone AT2H8. Anti-human EGFR mAb, clone AT6E3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human EGFR protein.
Immunogen Recombinant human EGFR (424-605aa) purified from E. coli
Form Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Reactivity Human
Applications Dot blot, ELISA, ICC, WB
Concentration 0.1 mg/ml
Working Dilutions Optimal dilution should be performed by user.
Species Mouse
Isotype K, IgG2b
Interest Fields Cancer
NCBI Number NP_005228
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
References Cohen S, (1964) Nat Cancer Inst Monogr, 13: 13-27. Toyoda H, et al. (1995) J Biol Chem, 270: 7495-500. Carpenter G, et al. (1978) Nature,276: 409-10.

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