Anti-EIF2S1 (clone AT5E10)

Antibodies, Monoclonal Antibodies
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Product Name Anti-EIF2S1 (clone AT5E10)
Description Eukaryotic translation initiation factor 2, subunit 1 alpha (EIF2S1) is plays a central role in initiating translation, and provides for a rate-limiting step in protein synthesis. The phosphorylation of alpha-subunit of EIF2S1 effectively prevents formation of the EIF2S1/GTP/Met-tRNAi complex and inhibits global protein synthesis.
Synonyms EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, Eukaryotic translation initiation factor 2 subunit 1 EIF 2 alpha, EIF 2, EIF 2A, EIF 2alpha, EIF2 alpha, Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa, Eukaryotic translation initiation factor 2 subunit 1 alpha, Eukaryotic translation initiation factor 2 subunit alpha.
Host Mouse
Clone AT5E10. Anti-human EIF2S1 mAb, clone 5E10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human EIF2S1 protein.
Immunogen Recombinant human EIF2S1 (1-315aa) purified from E. coli
Form Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Reactivity Human
Applications Dot blot, ELISA, WB
Concentration 0.1 mg/ml
Working Dilutions Optimal dilution should be performed by user.
Species Mouse
Isotype K, IgG2b
Interest Fields Signal Transduction
NCBI Number NP_004085
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
References Kim JH, et al. (2011). EMBO J, 10;30(12):2454-64 Pena J, et al. (2011). J Biol Chem, 286(16):14226-36. Muaddi H, et al. (2010). Mol Biol Cell, 21(18):3220-31

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