Anti-PPM1F (clone AT6D11)

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01-A0278
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Antibodies, Monoclonal Antibodies
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Product Name Anti-PPM1F (clone AT6D11)
Description PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Synonyms Protein phosphatase 1F, CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2
Host Mouse
Clone Anti-human PPM1F mAb, clone AT6D11, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PPM1F protein.
Immunogen Recombinant human PPM1F (1-454aa) purified from E. coli
Form Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.
Reactivity Human
Applications Dot blot, ELISA, WB
Concentration 0.1mg/ml
Working Dilutions Optimal dilution should be performed by user.
Species Mouse
Isotype IgG1, K
NCBI Number NP_055449
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
References Koh, CG., et al. (2002) Curr Biol 12(4): 317-21Tan, KM., et al. (2001) J Biol Chem 276(47): 44193-202

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