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|Product Name||Anti-PPM1F (clone AT6D11)|
|Description||PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.|
|Synonyms||Protein phosphatase 1F, CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2|
|Clone||Anti-human PPM1F mAb, clone AT6D11, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PPM1F protein.|
|Immunogen||Recombinant human PPM1F (1-454aa) purified from E. coli|
|Form||Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.|
|Applications||Dot blot, ELISA, WB|
|Working Dilutions||Optimal dilution should be performed by user.|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|References||Koh, CG., et al. (2002) Curr Biol 12(4): 317-21Tan, KM., et al. (2001) J Biol Chem 276(47): 44193-202|
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