Anti-SBDS (clone AT1E8)

Catalog
01-A0231
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Antibodies, Monoclonal Antibodies
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Product Name Anti-SBDS (clone AT1E8)
Description The Shwachman-Bodian-Diamond syndrome (SBDS) is 249 amino acid ribosome maturation protein. The precise function of the SBDS protein is not known but it appears to play an important role in actin cytoskeletal function and mitotic spindle stabilization. Also, SBDS is required for the assembly of mature ribosomes and ribosome biogenesis. Mutations in the SBDS gene cause Shwachman-Diamond syndrome (SDS). SDS is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities.
Synonyms Ribosome maturation protein SBDS, CGI-97, SDS, SWDS
Host Mouse
Clone AT1E8. Anti-human SBDS mAb, clone AT1E8, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SBDS protein.
Immunogen Recombinant human SBDS (1-250aa) purified from E. coli
Form Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Reactivity Human
Applications Dot blot, ELISA, WB
Concentration 0.1 mg/ml
Working Dilutions Optimal dilution should be performed by user.
Species Mouse
Isotype K, IgG2b
Interest Fields Metabolism
NCBI Number NP_057122
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
References Boocock G.R., et al. (2003) Nat Genet 33(1): 97€“101Orelio C., et al. (2011) PLoS ONE 6(6): e20727Savchenko., et al. (2005) J Biol Chem 280(19): 19213€“20

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