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|Product Name||Anti-XPA (clone AT37C5)|
|Description||XPA, also known as DNA repair protein complementing XP-A cells, belongs to the XPA family. This protein is involved in DNA excision repair. It Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A), which is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities.|
|Synonyms||DNA repair protein complementing XP-A cells, XP1, XPAC|
|Clone||Anti-human XPA mAb, clone AT37C5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human XPA protein.|
|Immunogen||Recombinant human XPA (1-273aa) purified from E. coli|
|Form||Liquid. Supplied in Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 0.02% Sodium Azide.|
|Applications||Dot blot, ELISA, WB|
|Working Dilutions||Optimal dilution should be performed by user.|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|References||Pan Y.R., et al. (2009) Cell Cycle 8:655-664|
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