Protocadherin Gamma A (pan) Antibody: APC

Category: Antibodies
Catalog
SMC-453D-APC
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Product Name Protocadherin Gamma A (pan) Antibody: APC
Description The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. . Mouse Anti-Mouse Protocadherin Gamma A (pan) Monoclonal IgG2b
Synonyms PCDH gamma A Antibody, PCDH-gamma-A Antibody, PCDHGA Antibody, Protocadherin gamma A Antibody, Protocadherin gamma subfamily A Antibody, Gamma Protocadherin A (pan) Antibody, Pan-Gamma-Protocadherin-A Antibody, Pan Gamma Protocadherin A Antibody
Host Mouse
Clone S144-32
Immunogen Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-A3. Human: 80% identity (68/84 amino acids identical) >75% identity with other Gamma-protocadherin-A proteins
Isotype IgG2b
Specificity Detects ~100kDa. Cross-reacts with other Gamma protocadherin-A proteins. No cross-reactivity against Gamma protocadherin-B or -C proteins.
Reactivity Human, Mouse, Rat
Applications ICC, IF, WB
Form Purified, in PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Gene Id NP_291064.1. 93711
Uniprot Q91XY5
Supplier Stressmarq Biosciences

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