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|Product Name||PTGDS, 23-190aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MAPEAQVSVQ PNFQQDKFLG RWFSAGLASN SSWLREKKAA LSMCKSVVAP ATDGGLNLTS TFLRKNQCET RTMLLQPAGS LGSYSYRSPH WGSTYSVSVV ETDYDQYALL YSQGSKGPGE DFRMATLYSR TQTPRAELKE KFTAFCKAQG FTEDTIVFLP QTDKCMTEQ|
|Background||Prostaglandin-H2 D-isomerase, also known as PTGDS, is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a beta-amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease. Recombinant human PTGDS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||0.5mg/ml (determined by BCA)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 200mM NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||14.0kDa (127aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)|
|NCBI Accession #||NP_000945|
|Purity||> 90% by SDS-PAGE|
|References||Hoffmann A., et al. (1993) J Neurochem. 61(2):451-6.
Giacomelli S., et al. (1996) Biochem Biophys Acta. 1310(3):269-76.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Prostaglandin-H2 D-isomerase, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2|
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