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|Product Name||RAB6B, 1-208aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS FQQTSKWIDD VRTERGSDVI IMLVGNKTDL ADKRQITIEE GEQRAKELSV MFIETSAKTG YNVKQLFRRV ASALPGMENV QEKSKEGMID IKLDKPQEPP ASEGGCSC|
|Background||RAB6B, also known as ras-related protein Rab-6B, belongs to Rab6 family of the small GTPase superfamily. The Rab6 subfamily consists of three different isoforms: Rab6A, Rab6A' and Rab6B. Both Rab6A and Rab6A' are ubiquitously expressed whereas Rab6B is predominantly expressed in brain. Rab6 is a key regulator in the retrograde transfer from endosomes via the Golgi to the ER and may function in retrograde tansport in neuronal cells. Recombinant human RAB6B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
|Concentration||0.25 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT.|
|Intended Use||For Research Use Only|
|Molecular Weight||33.5 kDa (308aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_057661|
|Purity||> 95% by SDS-PAGE|
|References||Wanschers B, et al. (2008), Cell Motil Cytoskeleton., 65:183-96.
Wanschers BF., et al. (2007). Exp Cell Res. 313:3408-20.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Ras-related protein Rab-6B, RAB6B, member RAS oncogene family|
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