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|Product Name||RAP1B, 1-181aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS C|
|Background||RAP1B belongs to a superfamily of RAS-like small GTP-binding proteins involved in cell signaling. It possesses intrinsic GTPase activity and is ubiquitously expressed in mammalian tissues. The putative effector domain of Ras proteins, whose integrity is required for cell transformation as well as interaction with the putative effector protein GAP, is conserved in both Rap 1 proteins. Recombinant human RAP1B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1.0 mg/ml (determined by BCA assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||26.1 kDa (237aa), confirmed by MALDI-TOF|
|NCBI Accession #||NP_056461|
|Purity||> 90% by SDS-PAGE|
|References||Awasthi A., et al. (2010) J Exp Med. 207(9):1923-38.
Schoenwaelder SM., et al. (2010) J Biol Chem. 285(4):2886-96.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Ras-related protein Rap-1b, DKFZp586H0723, K-REV, RAL1B|
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