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|Product Name||RGN, 1-299aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MSSIKIECVL PENCRCGESP VWEEVSNSLL FVDIPAKKVC RWDSFTKQVQ RVTMDAPVSS VALRQSGGYV ATIGTKFCAL NWKEQSAVVL ATVDNDKKNN RFNDGKVDPA GRYFAGTMAE ETAPAVLERH QGALYSLFPD HHVKKYFDQV DISNGLDWSL DHKIFYYIDS LSYSVDAFDY DLQTGQISNR RSVYKLEKEE QIPDGMCIDA EGKLWVACYN GGRVIRLDPV TGKRLQTVKL PVDKTTSCCF GGKNYSEMYV TCARDGMDPE GLLRQPEAGG IFKITGLGVK GIAPYSYAG|
|Background||RGN (Regucalcin) belongs to the SMP-30/CGR1 family. This protein is Ca (2+)-binding protein that does not contain EF-hand motif of Ca (2+)-binding domain. RGN plays a pivotal role in the keep of intracellular Ca2+ homeostasis due to activating Ca2+ pump enzymes in the plasma membrane (basolateral membrane), microsomes (endoplasmic reticulum) and mitochondria of many cells. Also, it plays a multifunctional role in the regulation of cell functions in liver, kidney cortex, heart and brain and a suppressor protein for cell signaling systems in many cell types.|
|Concentration||0.25mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 40% glycerol, 200mM NaCl, 1mM EDTA|
|Intended Use||For Research Use Only|
|Molecular Weight||51.1kDa (447a), confirmed by MALDI-TOF|
|NCBI Accession #||NP_690608|
|Purity||> 85% by SDS-PAGE|
|References||Chakraborti S., et al. (2010) Biochemistry. 49:3436-3444
Yamaguchi M., et al. (2005) Int J Mol Med. 15: 372-389
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Regucalcin, RC, SMP30|
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