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|Product Name||RGS16, 1-202aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE FICSEAPKEV NIDHETRELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL AAQASAASAT LSSCSLDEPS HT|
|Background||RGS16, also known as regulator of G-protein signaling 16, belongs to 'regulator of G protein signaling' family and negatively regulates G protein coupled receptor signalling. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP bound form. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Recombinant RGS16 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||25.1 kDa (224aa), confirmed by MALDI-TOF.|
|NCBI Accession #||AAH06243|
|Purity||> 90% by SDS-PAGE|
|References||Chen C., et al. (1997) J Biol Chem. 272(13):8679-85
Derrien A., et al. (2001) J Biol Chem. 276(51):48532-8
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||A28-RGS14, A28-RGS14P, RGS-R, Regulator of G-protein signaling 16 A28 RGS14, A28 RGS14P, HGNC:9997, Regulator of G protein signaling 16, Retinally abundant regulator of G protein signaling, RGS 16 RGS R, Rgs14, RGSR.|
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