RhoG, 1-188aa, Human

Proteins, Recombinant
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Product Name RhoG, 1-188aa, Human
Applications SDS-PAGE
Background RhoG(Ras homology Growth-related) is a member of the Rac subfamily of the Rho family of small G proteins. RhoG is a small monomeric GTP-binding protein (G protein), and is an important component of many intracellular signalling pathways. This protien are required for the formation of membrane ruffles during macropinocytosis. It plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. Like most small G proteins RhoG is involved in a diverse set of cellular signalling mechanisms. In mammalian cells these include cell motility, gene transcription, endocytosis, neurite outgrowth, protection from anoikis and regulation of the neutrophil NADPH oxidase. Recombinant human RhoG protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 45 kDa (403aa) confirmed by MALDI-TOF
NCBI Accession # NP_001656
Purity > 90% by SDS-PAGE
References van Buul J.D., et al. (2007) J. Cell Biol. 178:1279-1293
Ellerbroek S.M., et al. (2004) Mol. Biol. Cell 15:3309-3319
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms Rho-related GTP-binding protein RhoG, ARHG
Tag His-tag

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