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|Product Name||SAA4, 21-130aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MWRSFFKEAL QGVGDMGRAY WDIMISNHQN SNRYLYARGN YDAAQRGPGG VWAAKLISRS RVYLQGLIDY YLFGNSSTVL EDSKSNEKAE EWGRSGKDPD RFRPDGLPKK Y|
|Background||SAA4 is a constitutively expressed protein belonging to the SAA family. It is a major acute phase reactant and an apolipoprotein of the HDL complex. SAA4 is constitutively expressed only in humans and mice, is associated almost entirely with lipoproteins of the high density range. Its physiological function is unknown and its serum concentration has no relationship with those of other major apolipoproteins. The presence of SAA4 mRNA and protein in macrophage derived foam cells of coronary and carotid arteries suggested a specific role of human SAA4 during inflammation including atherosclerosis. Recombinant human SAA4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||33 kDa (300aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)|
|NCBI Accession #||NP_006503|
|Purity||> 90 % by SDS-PAGE|
|References||Badolato R., et al. (2000) J Leukoc Biol. 67(3):381-6.
Artl A., et al. (2000) Arterioscler Thromb Vasc Biol. 20(3):763-72.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Serum amyloid A-4 protein, C-SAA, CSAA|
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