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|Product Name||SAP18, 20- 172aa, Human, Recombinant|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY|
|Background||SAP18, also known as Sin3A-associated protein, is component of the histone deacetylase complex that plays an important role in the regulation of eukaryotic gene expression. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. It also has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. Recombinant SAP18 protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Form||Liquid, in 10 mM Sodium citrate pH 3.5, 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||15.8 kDa (141aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_005861|
|Purity||> 90% by SDS-PAGE|
|References||Zhang Y., et al. (1997) Cell. 89(3):357-64.
Matyash A, et al. (2009) J Biol Chem. 284(5):3012-20.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Sin3A-associated protein, 2HOR0202, SAP18P, SAP18, Sin3A-associated protein, 18kDa Histone deacetylase complex subunit SAP18, Sin3-associated polypeptide p18.|
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