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|Product Name||SELH (SC44C), 1-122aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMAPRGRK RKAEAAVVAV AEKREKLANG GEGMEEATVV IEHCTSCRVY GRNAAALSQA LRLEAPELPV
KVNPTKPRRG SFEVTLLRPD GSSAELWTGI KKGPPRKLKF PEPQEVVEEL KKYLS
|Background||SELH is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. The exact function of this gene is not known, however, selenoproteins are thought to be responsible for most biomedical effects of dietary selenium. Recombinant human SELH protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||54.4 kDa (468aa)|
|NCBI Accession #||NP_734467|
|Purity||> 90% by SDS-PAGE|
|References||Panee J, Stoytcheva ZR, et al. (2007). J Biol Chem. 282(33):23759-65.
Novoselov SV, Kryukov GV, et al. (2007). J Biol Chem. 282(16):11960-8.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||Selenoprotein H, C17orf10, SELH|
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