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|Product Name||Serpin A5, 20-406aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MHRHHPREMK KRVEDLHVGA TVAPSSRRDF TFDLYRALAS AAPSQNIFFS PVSISMSLAM LSLGAGSSTK MQILEGLGLN LQKSSEKELH RGFQQLLQEL NQPRDGFQLS LGNALFTDLV VDLQDTFVSA MKTLYLADTF PTNFRDSAGA MKQINDYVAK QTKGKIVDLL KNLDSNAVVI MVNYIFFKAK WETSFNHKGT QEQDFYVTSE TVVRVPMMSR EDQYHYLLDR NLSCRVVGVP YQGNATALFI LPSEGKMQQV ENGLSEKTLR KWLKMFKKRQ LELYLPKFSI EGSYQLEKVL PSLGISNVFT SHADLSGISN HSNIQVSEMV HKAVVEVDES GTRAAAATGT IFTFRSARLN SQRLVFNRPF LMFIVDNNIL FLGKVNRP|
|Background||Serpin A5, also known as PCI (Protein C Inhibitor) or PAI3 (plasminogen activator inhibitor 3), is a member of the serpin serine proteinase inhibitor family. This protein inhibits plasminogen activators as well as activated protein C. Serpin A5 is secreted in plasma, but is also expressed in liver. Serpin A5 is involved in cell inflammation, proliferation, apoptosis, tumour cell migration, invasion, and metastasis. Recombinant Serpin A5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||20 mM Tris-HCl buffer, (pH8.0) , 10% Glycerol, 1mM DTT, 0.1M NaCl|
|Intended Use||For Research Use Only|
|Molecular Weight||28.3 kDa (270aa), confirmed by MALDI-TOF.|
|NCBI Accession #||AAH08915|
|Purity||> 90% by SDS-PAGE|
|References||Han MH., et al. (2008) Nature. 451(7182):1076-81.
Li W., et al. (2008) J Biol Chem. 283(51):36039-45.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||PAI3, PCI, PROCI, Protein C inhibitor, Serpin peptidase inhibitor, clade A, member 5 Acrosomal serine protease inhibitor, IPSP, PAI 3, PLANH 3, PLANH3, Plasma serine protease inhibitor, Plasminogen activator inhibitor 3, Plasminogen activator inhibitor III, Serpin A5, Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5, Serpin peptidase inhibitor clade A member 5, SerpinA5.|
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