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|Product Name||SET7/9 Histone methyltransferase Human, Recombinant|
|Amino Acid Sequence||MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK|
|Background||Set 7/9 is a histone methyltransferase(HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine(AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression. Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. Set7/9, unlike most other SET proteins, is exclusively a mono-methylase.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Form||Liquid, in 20 mM Tris pH 8.0, 1 mM EDTA, 2mM MgCl2, 10% Glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||23 kDa (200 aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_085151|
|Purity||> 95% by SDS-PAGE|
|References||Xiao B., et al. (2003) Nature. 421(6923):652-6.
Kwon T., et al. (2003) EMBO J. 22, 292-303.
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||SETD7, KIAA1717, KMT7, SET7, SET9, SET7/9 Histone methyltransferase, EC 188.8.131.52, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, SET domain-containing protein 7, SET7/9, Lysine N-methyltransferase 7, Histone-lysine N-methyltransferase SETD7, SET domain-containing protein 7 FLJ21193, H3 K4 HMTase, H4 lysine-4 specific, Histone H3 K4 methyltransferase, Histone H3 lysine 4 specific methyltransferase, Histone H4-K4 methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specific SET7, Histone-lysine N-methyltransferase, Lysine methyltransferase, SET 7, SET 7/9, SET 9, SET D7, SET domain containing protein 7, SET domain-containing protein 8,|
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