| Product Name | SHANK3 Antibody: ATTO 700 |
|---|---|
| Description | Shank proteins make up a family of scaffold proteins identified through their interaction with a variety of membrane and cytoplasmic proteins (1). Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. Shank proteins are also crucial in receptor tyrosine kinase signaling; specifically, Shank3 can mediate Erk-MAPK and P13K signaling which is crucial for tubule formation (2). Shank3 is also one of the latest genes to be associated with autism. A mutation of a single copy of Shank3 on chromosome 22q13 can result in language and/or social communication disorders (3). Mouse Anti-Rat SHANK3 Monoclonal IgG2b |
| Synonyms | AI841104 antibody, DEL22q13.3 antibody, KIAA1650 antibody, Proline rich synapse associated protein 2 antibody, Proline-rich synapse-associated protein 2 antibody, ProSAP2 antibody, PSAP2 antibody, SH3 and multiple ankyrin repeat domains 3 antibody, SH3 an |
| Host | Mouse |
| Clone | S69-46 |
| Immunogen | Synthetic peptide amino acids 840-857 of rat Shank3 |
| Isotype | IgG2b |
| Specificity | Detects ~190kDa. No cross-reactivity against Shank1 or Shank2. |
| Reactivity | Human, Mouse, Rat |
| Applications | AM, ICC, IF, IHC, IP, WB |
| Form | Purified, in PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Gene Id | NP_067708.1. 59312 |
| Uniprot | Q9JLU4 |
| Supplier | Stressmarq Biosciences |
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