SHH, 24-197aa, Human

Proteins, Recombinant
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Product Name SHH, 24-197aa, Human
Applications SDS-PAGE
Background SHH, also known as Sonic hedgehog protein, is one of three proteins in the mammalian signaling pathway family called hedgehog. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. It controls cell division of adult stem cells and has been implicated in development of some cancers. Recombinant human SHH protein, fused to His-tag at C-terminus was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 0.5mg/ml (determined by Bradford assay)
Form Liquid, in Phosphate Buffered Saline pH7.4 containing 10% glycerol
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 55.7 kDa (508aa), confirmed by MALDI-TOF
NCBI Accession # NP_000184
Purity > 95% by SDS-PAGE
References Marigo V, et al. (1996) Proc Natl Acad Sci U S A. 93(18):9346-51
Kolpak A, et al. (2005) J Neurosci. 25(13):3432-41
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms HHG1, HLP3, HPE3, SMMCI, TPT, TPTPS, Sonic hedgehog protein HHG 1, HLP 3, Holoprosencephaly 3, HPE 3, MCOPCB5, SHH, SMMC I, SMMCI, Sonic Hedgehog (Drosophila) homolog, sonic hedgehog homolog (Drosophila), Sonic hedgehog homolog,
Tag His-tag

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