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|Product Name||SIGLEC2 [TPD44/D11] Monoclonal Antibody|
|Background||SIGLEC-2 (CD22) is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias.|
|Immunogen||B cell lymphoma cells|
|Synonyms||CD22 Antigen, Sialic Acid Binding Ig-Like Lectin 2, B-Lymphocyte Cell Adhesion Molecule, T-Cell Surface Antigen Leu-14, SIGLEC-2, BL-CAM|
|Target||Sialic acid binding Ig-like lectin 2 (SIGLEC2, CD22, BL-CAM)|
|Applications||Fluorescence-Activated Cell Sorting, Immunohistochemistry|
|Intended Use||For Research Use Only|
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