SOD (EC) Antibody: FITC

Category: Antibodies
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SMC-167D-FITC
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Product Name SOD (EC) Antibody: FITC
Description Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (6). SOD3 can also be distinguished by its heparin-binding capacity (1). . Mouse Anti-Human SOD (EC) Monoclonal IgG1 Kappa
Synonyms EC SOD antibody, EC-SOD antibody, Extracellular superoxide dismutase [Cu Zn] antibody, Extracellular superoxide dismutase [Cu-Zn] antibody, Extracellular superoxide dismutase antibody, Extracellular superoxide dismutase precursor antibody, MGC20077 antibo
Host Mouse
Clone 4GG11G6
Immunogen Human extracellular SOD purified from aortas
Isotype IgG1 kappa
Specificity Detects extracellular SOD ~35kDa.
Reactivity Guinea Pig, Human, Mouse, Rat
Applications ELISA, ICC, IF, IHC, WB
Form Purified, in PBS pH7.4, 50% glycerol, 0.09% sodium azide
Gene Id NP_003093.2. 6649
Uniprot P08294
Supplier Stressmarq Biosciences

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