SUB1, 1-127aa, Human

Proteins, Recombinant
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Product Name SUB1, 1-127aa, Human
Applications SDS-PAGE
Background SUB1, also known as PC4, is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. SUB1 interacts with the activation domain of transcription factor IIA (TFIIA) and TATA-binding protein (TBP)-associated factors (TAFs) to directly bind to double stranded DNA. This protein induces both activation and repression of RNAPII basal transcription, depending on the presence or absence of these transcription factors and holoenzyme components. Recombinant human SUB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 0.1M NaCl
Species Human
Host E.coli
Intended Use For Research Use Only
Molecular Weight 29.0 kDa (261aa), confirmed by MALDI-TOF
NCBI Accession # NP_006704
Purity > 90% by SDS-PAGE
References Tavenet A., et al. (2009) Proc Natl Acad Sci U S A. 106(34):14265-70.
Scott KL., et al. (2009) Nature. 459(7250):1085-90.
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Synonyms : p14, P15, PC4, Activated RNA polymerase II transcriptional coactivator p15 Activated RNA polymerase II transcriptional coactivator p15, Interferon related developmental regulator 1, MGC102747, PC4 LSB, Positive cofactor 4, RPO2TC1, SUB1, SUB1 homolog.
Tag His-tag

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