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|Product Name||14-3-3 eta, 1-246aa, Human, Recombinant|
|Background||The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon,sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3eta (eta), a subtype of the 14-3-3 family of proteins, was found in B cells, brain, cerebrospinal fluid etc. 14-3-3eta interacts with and relocalizes the A20 zinc finger protein from the insoluble to the soluble fraction, suggesting a chaperone function. Recombinant human 14-3-3eta, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography techniques.|
|Synonyms||YWHA1, YWHAH, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, 14-3-3 eta, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 14 3 3 protein eta, HGNC:12853, Protein AS1, Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein eta polypeptide, Tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide, YWHA 1.|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE KELETVCNDV LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN|
|Molecular Weight||57 kDa (511 aa), confirmed by MALDI-TOF.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in Phosphate-Buffered Saline (pH 7.4)|
|Purity||> 95% by SDS-PAGE|
|NCBI Accession #||NP_003396|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Sato S., et al. (2006) EMBO J 25(1):211-21
Chen J., et al. (2007), J Neurosci Res. 85(8):1724-33
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