4-1BB ligand, 71-254aa, Human, Recombinant

Catalog
01-2073
$0.00
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Proteins, Recombinant
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Product Name 4-1BB ligand, 71-254aa, Human, Recombinant
Background 4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease. Recombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms Tumor necrosis factor ligand superfamily member 9, TNFSF9, 4-1BBL, CD137L, 4-1BB ligand, 4 1BB L, 4 1BB ligand, 4 1BBL, Cd137l, Cd157l, homolog of mouse 4 1BB L, homolog of mouse 4 1BBL, ILA ligand (TNF related), Ly63l, receptor 4 1BB ligand, Tumor necrosis factor (ligand) superfamily member 9.
Species Human
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTG GLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE
Molecular Weight 53.9 kDa (479 aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl (pH8.0) buffer containing 10% glycerol
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_003802
Host E.coli
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Lee SW., et al. (2008). Nat Immunol. 9(8):917-26
Sharma RK., et al. (2009). Cancer Res. 69(10):4319-26

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