4-1BB Ligand, Human, Recombinant

Proteins, Recombinant
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Product Name 4-1BB Ligand, Human, Recombinant
Description 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.
Synonyms TNFSF9, CD137L
Biological Activity Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED 50 for this effect is 5-10 ng/ml.
Please Note: Results may vary with PBMC donors.
Endotoxin Level Endotoxin level is <0.1 ng/ug of protein (<1EU/ug).
Source E. coli
Purity 98%
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
Cross Reactivity NULL

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