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|Product Name||AKAP7, 1-81aa, Human|
|Background||AKAP7 (A-kinase anchor protein 7 isoform gamma isoform alpha), also known as AKAP18, belongs to the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAP 7 is expressed in brain, heart, lung, pancreas and skeletal muscle. AKAP 7 binds PKA to the plasma membrane, and permits functional coupling to the L-type calcium channel. Recombinant human AKAP7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||A-kinase anchor protein 7 isoform gamma isoform alpha, AKAP15, AKAP18|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSHMGQLCC FPFSRDEGKI SEKNGGEPDD AELVRLSKRL VENAVLKAVQ QYLEETQNKN KPGEGSSVKT EAADQNGNDN ENNRK|
|Molecular Weight||20 kDa (193aa), confirmed by MALDI-TOF|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_004833|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Trotter K.W., et al. (1999) J. Cell Biol. 147:1481-1492
Klussmann, E., et al. (2001) Kidney Int. 60: 446-449.
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