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|Product Name||Alcohol dehydrogenase, 1-325aa, Human|
|Background||Alcohol dehydrogenase [NADP+] (AKR1A1) is a member of the aldo/keto reductase superfamily and catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. This protein is closely related (65% identity) to aldose reductase, an enzyme involved in the pathogenesis of some diabetic and galactosemic complications. It plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Recombinant human Alcohol dehydrogenase was expressed in E.coli and purified by using conventional chromatography techniques.|
|Synonyms||AKR1A1, ALDR1, ALR, ARM, DD3, Alcohol dehydrogenase [NADP+] Alcohol dehydrogenase, Aldehyde reductase, aldo-keto reductase family 1 member A1 (aldehyde reductase).|
|Amino Acid Sequence||MAASCVLLHT GQKMPLIGLG TWKSEPGQVK AAVKYALSVG YRHIDCAAIY GNEPEIGEAL KEDVGPGKAV PREELFVTSK LWNTKHHPED VEPALRKTLA DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTICYDSTHY KETWKALEAL VAKGLVQALG LSNFNSRQID DILSVASVRP AVLQVECHPY LAQNELIAHC QARGLEVTAY SPLGSSDRAW RDPDEPVLLE EPVVLALAEKYGRSPAQILL RWQVQRKVIC IPKSITPSRI LQNIKVFDFT FSPEEMKQLN ALNKNWRYIV PMLTVDGKRV PRDAGHPLYP FNDPY|
|Molecular Weight||73.2 kDa (663aa)|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 10% glycerol|
|Purity||> 90% by SDS-PAGE|
|NCBI Accession #||NP_006057|
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Intended Use||For Research Use Only|
|References||Bohren KM., et al. (1989) J Biol Chem. 264(16): 9547-51.
Vander Jaqt DL., et al. (1990) J Biol Chem. 265(19):10912-8.
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