Annexin A1, 1-346aa, Human, Recombinant

Catalog
01-2062
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Proteins, Recombinant
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Product Name Annexin A1, 1-346aa, Human, Recombinant
Background Annexin A1, also known as Lipocortin I, belongs to a family of Ca(2+)-dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. It promotes membrane fusion and is also involved in exocytosis. Since Annexin A1 has phospholipase A2 inhibitory activity to bind from two to four calcium ions with high affinity, this protein may have potential anti-inflammatory activity. The detection of this protein by immunocytochemical means reportedly provides a simple, highly sensitive and specific assay for diagnosis of hairy cell leukemia. Recombinant human Annexin A1 protein was expressed in E.coli and purified by using conventional chromatography.
Synonyms Annexin-1, Lipocortin I, Calpactin II, Chromobindin-9, p35, ANXA1, ANX1, LPC1, Annexin I, AnnexinA1, AnnexinI, ANX 1, ANX A1, ANXA 1, ANXA1 protein, CalpactinII, Chromobindin 9, Chromobindin9, HGNC:533, Lipocortin 1, Lipocortin I, Lipocortin1, LipocortinI, LPC 1, Phospholipase A2 inhibitory protein,
Species Human
Amino Acid Sequence MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL TGHLEEVVLA LLKTPAQFDA DELRAAMKGL GTDEDTLIEI LASRTNKEIR DINRVYREEL KRDLAKDITS DTSGDFRNAL LSLAKGDRSE DFGVNEDLAD SDARALYEAG ERRKGTDVNV FNTILTTRSY PQLRRVFQKY TKYSKHDMNK VLDLELKGDI EKCLTAIVKC ATSKPAFFAE KLHQAMKGVG TRHKALIRIM VSRSEIDMND IKAFYQKMYG ISLCQAILDE TKGDYEKILV ALCGGN
Molecular Weight 27 kDa (237 aa), confirmed by MALDI-TOF.
Concentration 1 mg/ml (determined by Bradford assay)
Form Liquid, in 20mM Tris-HCl (pH8.0) buffer containing 30% glycerol
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI Accession # NP_000691
Host E.coli
Tag His-tag
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Lim LH., et al. (2007). FASEB J. 21(4):968-75
Kovacic RT., et al. (1991). Biochemistry. 30(37):9015-21

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