| Product Name | Anti-26S Proteasome (19S Cap Complex) Monoclonal Antibody |
|---|---|
| Description | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. Mouse Monoclonal Antibody to 26S Proteasome (19S Cap Complex). |
| Clone | P52 (26S-17) (17.14.1) |
| Immunogen | 26S proteasomes purified from Xenopus laevis ovary |
| Isotype | IgG1 |
| Specificity | The p52 subunit (Mr 52.000) is the major antigen of the 19S cap complex, which is a subcomplex of the 26S proteasome, implicated in ATP- and ubiquitin-dependent protein degradation. |
| Reactivity | Amphibian, Human, Mouse, Rat |
| Applications | WB |
| Form | Hybridoma culture supernatant |
| Storage | 2-8C |
| References | Peters JM et al. (1990) Embo J 9: 1757-1767Peters JM et al. (1992) J Mol Biol 223: 557-571 |
| Supplier | ARP |
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